Cancer Weekly
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Antisense Technology
Recent findings in antisense technology described by researchers from Harvard University
November 4th, 2008
According to recent research published in the journal Molecular and Cellular Biology, "Substantial data indicate that microRNA 21 (miR-21) is significantly elevated in glioblastoma (GBM) and in many other tumors of various origins. This microRNA has been implicated in various aspects of carcinogenesis, including cellular proliferation, apoptosis, and migration." "We demonstrate that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs). Specific inhibition of miR-21 with antisense oligonucleotides...
Source: Cancer Weekly (2008-11-04)
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