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Apoptosis
Researchers at McGill University target apoptosis
November 4th, 2008
According to recent research from Montreal, Canada, "The carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is downregulated in colonic and intestinal hyperplastic lesions as well as in other cancers, where it functions as a tumor suppressor. To investigate the functions of CEACAM1 in the normal intestine and in intestinal tumors, we generated a compound knockout mouse model and examined both Ceacam1(-/-) and Apc(1638N/+): Ceacam1(-/-) mice." "Ceacam1(-/-) intestinal cells exhibited a significant decrease in apoptosis, with no change in proliferation or migration, however. Compound Apc(1638N/+): Ceacam1(-/-) mice demonstrated an increase in intestinal tumor...
Source: Cancer Weekly (2008-11-04)
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