Cancer Weekly
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B-Cell Lymphoma
Research from G. Roue and co-researchers in the area of B-cell lymphoma described
November 4th, 2008
"Cyclin D1 is a key regulator of cell proliferation. It also controls other aspects of the cell fate, such as cellular senescence, apoptosis and tumourigenesis," investigators in Barcelona, Spain report. "We used B-lymphoid cell lines producing cyclin D1 to investigate the role of this protein in B-cell lymphomas and leukaemias. Constitutive low levels of cyclin D1 had no effect per se on cell proliferation, but conferred resistance to various apoptotic stimuli in B cells. Activation of the proapoptotic protein, Bax, was reduced and mitochondrial permeabilization and phosphatidylserine exposure following cytokine withdrawal were delayed in cyclin D1-producing cells....
Source: Cancer Weekly (2008-11-04)
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