Published in Cancer Weekly, November 4th, 2008
"We have previously reported that recurrent colorectal tumours demonstrate altered growth dynamics, increased metastatic burden and resistance to apoptosis, mediated by upregulation of phosphoinositide-3-kinase/Akt (PI3K/Akt). We investigated whether similar characteristics were evident in a model of locally recurrent breast cancer. Tumours were generated by orthotopic inoculation of 4T1 cells in two groups of...
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