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Cancer Vaccines
Research findings from J.A. Berzofsky et al update understanding of cancer vaccines
November 11th, 2008
"There are many mechanisms that regulate and dampen the immune response to cancers, including several types of regulatory T cells. Besides the T reg cell, we have identified another immunoregulatory circuit initiated by NKT cells that produce IL-13 in response to tumor growth and this IL-13 then induces myeloid cells to make TGF-beta that inhibits cytotoxic T cell-mediated tumor immunosurveillance in several mouse tumor models," scientists writing in the journal Cancer Immunology Immunotherapy report. "This finding created a paradox in the role of NKT cells in tumor immunity, in that they can also contribute to protection. We resolve this paradox by the finding...
Source: Cancer Weekly (2008-11-11)
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