Cancer Weekly
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Cancer Vaccines
Study findings from E. Huarte et al provide new insights into cancer vaccines
November 11th, 2008
According to recent research from Lebanon, "Dendritic cells (DC) and cytokines that expand myeloid progenitors are widely used to treat cancer." "Here, we show that CD11c(+)DEC205(+) DCs coexpressing alpha-smooth muscle actin and VE-cadherin home to perivascular areas in the ovarian cancer microenvironment and are required for the maintenance of tumor vasculature. Consequently, depletion of DCs in mice bearing established ovarian cancer by targeting different specific markers significantly delays tumor growth and enhances the effect of standard chemotherapies. tumor growth restriction was associated with vascular apoptosis after DC ablation followed by necrosis, which...
Source: Cancer Weekly (2008-11-11)
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