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Gene Therapy
Research reports on gene therapy from National Heart, Lung, & Blood Institute provide new insights
November 11th, 2008
According to recent research published in the journal Molecular Therapy, "Insertional mutagenesis continues to be a major concern in hematopoietic stem-cell gene therapy. Nonconventional gene transfer vectors with more favorable integration features in comparison with conventional retrovirus and lentivirus vectors are being developed and optimized." "In this study, we report for the first time a systematic analysis of 198 avian sarcoma leukosis virus (ASLV) insertion sites identified in rhesus long-term repopulating cells, and a comparison of ASLV insertion patterns to Moloney murine leukemia virus (MLV) (n = 396) and simian immunodeficiency virus (SIV) (n = 289)...
Source: Cancer Weekly (2008-11-11)
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