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Cancer Weekly

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Cancer Gene Therapy



Researchers from Nanjing University report on findings in cancer gene therapy



November 11th, 2008

Researchers detail in 'Growth inhibition of a tongue squamous cell carcinoma cell line (Tca8113) in vitro and in vivo via siRNA-mediated down-regulation of skp2,' new data in cancer gene therapy. "Human S-phase kinase-associated protein (skp) 2, the specific ubiquitin ligase subunit that targets the negative regulator p27(Kip1) of the cell cycle and brings about its degradation, is overexpressed in various cancers, including human oral squamous cell carcinomas; its expression levels are inversely related to those of p27(Kip1) in these cells. Recently, a technique known as RNA interference (RNAi) has successfully been applied to mammalian cells," scientists in Nanjing, People's Republic of...


Source: Cancer Weekly (2008-11-11)

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