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Cancer Gene Therapy
Study findings from National Taiwan University, Department of Pharmacology broaden understanding of cancer gene therapy
November 11th, 2008
Data detailed in 'YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway' have been presented. "The aim of this study was to elucidate the mechanism of YC-1{3-(5'-hydroxy methyl-2'-furyl)-1-benzylindazole}-induced human renal carcinoma cells apoptosis and to evaluate the potency of YC-1 in models of tumor growth in mice. EXPERIMENTAL APPROACH: YC-1-mediated apoptosis was assessed by analysis of MTT, SRB, DAPI staining and flow cytometry analysis," scientists in Taipei, Taiwan report. "Knockdown of JNK protein was achieved by transient transfection using siRNA. The mechanisms of action of YC-1 on different...
Source: Cancer Weekly (2008-11-11)
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