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Non-Small Cell Lung Cancer

New findings from P.A. Zucali and co-authors in the area of non-small cell lung cancer published

Published in Cancer Weekly, November 11th, 2008

"Approximately 10% of unselected non-small-cell lung cancer (NSCLC) patients responded to the epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) treatment. However, resistance mechanisms are not well understood," researchers in the United States report.

"We evaluated several potential biological markers of intrinsic EGFR-TKIs-resistance in NSCLC. pAKT, pERK, cSRC, E-cadherin, cMET[pY1003], cMET[pY1230/1234/1235], and cMET[pY1349] immunohistochemistry, cMET FISH analysis, and EGFR-, KRAS-, and cMET mutation analysis were carried out on tumor samples from 51 gefitinib-treated NSCLC patients. Biological parameters and survival end points were compared...

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