Ovarian Cancer

New findings from Temple University, Medical Department in the area of ovarian cancer published

Published in Cancer Weekly, November 11th, 2008

"Rb2/p130 tumor suppressor protein regulates cell cycle progression primarily through interactions with members of the E2F family of transcription factors and repression of the transactivation of E2F target genes. In ATRA sensitive ovarian carcinoma CA-OV3 cells, a dramatic increase in Rb2/p130 protein mediates growth arrest at GO/G1," researchers in the United States report.

"However, although Rb2/p130 is expressed at high levels in SKOV3 cells, they fail to growth arrest in response to ATRA treatment. We show that the functional activity of Rb2/p 130 in SK-CV3 cells is reduced when compared to CA-OV3 cells. To determine the basis for the reduced functional activity,...

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Source: Cancer Weekly (2008-11-11)

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