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Addiction Medicine
Investigators at Massachusetts General Hospital have published new data on addiction medicine
November 11th, 2008
"The clinical efficacy of selective kinase inhibitors suggests that some cancer cells may become dependent on a single oncogene for survival. RNAi has been increasingly used to understand such ''oncogene addiction'' and validate new therapeutic targets," researchers in the United States report. "However, RNAi approaches suffer from significant off-target effects that limit their utility. Here, we combine carefully titrated lentiviral-mediated short hairpin RNA knockdown of the epidermal growth factor receptor (EGFR) with heterologous reconstitution by EGFR mutants to rigorously analyze the structural features and signaling activities that determine addiction to the...
Source: Cancer Weekly (2008-11-11)
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