Cancer Weekly
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Adenovirus
Research from State University of New York provides new data about adenovirus
November 11th, 2008
According to recent research from the United States, "Classic but also novel roles of p53 are becoming increasingly well characterized. We previously showed that ex vivo retroviral transfer of mitochondrially targeted wild type p53 (mitop53) in the E mu-myc mouse lymphoma model efficiently induces tumor cell killing in vivo." "In an effort to further explore the therapeutic potential of mitop53 for its pro-apoptotic effect in solid tumors, we generated replication-deficient recombinant human Adenovirus type 5 vectors. We show here that adenoviral delivery of mitop53 by intratumoral injection into HCT116 human colon carcinoma xenograft tumors in nude mice is surprisingly...
Source: Cancer Weekly (2008-11-11)
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