Cancer Weekly
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Aging
New aging research from V.N. Anisimov et al outlined
November 11th, 2008
According to recent research published in the journal Cell Cycle, "Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects of calorie restriction are due to decreasing IGF-1 levels." "A search of pharmacological modulators of insulin/IGF-1 signaling pathway (which resemble effects of life span extending mutations or calorie restriction) could be a perspective direction in regulation of longevity. Antidiabetic biguanides are most promising among them. Here we show the chronic treatment of female outbred SHR mice with...
Source: Cancer Weekly (2008-11-11)
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