Cancer Weekly
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Angiogenesis
Research results from University of Freiburg update knowledge of angiogenesis
November 11th, 2008
According to recent research from Freiburg, Germany, "Several lines of evidence indicate that Flt-1, a fms-like tyrosine kinase receptor, which binds to vascular endothelial growth factor (VEGF)-A, VFGF-B, and PIGF, is a positive regulator of angiogenesis in the context of tumor growth and metastasis. However, the molecular basis of its action is still not clear." "Besides endothelial cells, Flt-1 is also expressed by other different cell types, including myeloid hematopoeitic cells (monocytes and macrophages). To examine the functions of Flt-1 expressed by bone marrow-derived myeloid cells in supporting tumor growth and angiogenesis, Flt-1 tyrosine kinase-deficient...
Source: Cancer Weekly (2008-11-11)
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