Cancer Weekly
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Antifungals
Studies from M. Odriscoll et al have provided new data on antifungals
November 11th, 2008
"N-Thiolated beta-lactams had previously been shown to have antibacterial activity against a narrow selection of pathogenic bacteria including Staphylococcus aureus and Bacillus anthracis, as well as apoptotic-inducing activity in a variety of human cancer cell lines," investigators in the United States report. "We now have found that these lactams also possess antifungal activity against Candida and other fungi by exerting powerful cytostatic effects that disrupt the structural integrity of cytoplasmic membranes," wrote M. Odriscoll and colleagues. The researchers concluded: "The mode of action and structure-activity trends of these lactams as...
Source: Cancer Weekly (2008-11-11)
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