Cancer Weekly
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Antisense Technology
Research from W.A. Scaringe and co-authors in the area of antisense technology published
November 11th, 2008
According to recent research from the United States, "Somatic microindels (microdeletions with microinsertions) have been studied in normal mouse tissues using the Big Blue lacI transgenic mutation detection system. Here we analyze microindels in human cancers using an endogenous and transcribed gene, the TP53 gene." "Microindel frequency, the enhancement of 1-2 microindels and other features are generally similar to that observed in the non-transcribed lacI gene in normal mouse tissues. The current larger sample of somatic microindels reveals recurroids: mutations in which deletions are identical and the co-localized insertion is similar. The data reveal that the...
Source: Cancer Weekly (2008-11-11)
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