Cancer Weekly
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Apoptosis
Findings from University of Texas advance knowledge in apoptosis
November 11th, 2008
According to a study from the United States, "The histone deacetylase inhibitor SAHA enhances cell death stimulated by the proteasome inhibitor bortezomib (BZ) by disrupting BZ-induced aggresome formation. Here we report that Myc regulates the sensitivity of multiple myeloma ( MM) cells to BZ + SAHA-induced cell death." "In MM cells, Myc expression directly correlated with intracellular ER content, protein synthesis rates, the percentage of aggresome-positive cells, and the sensitivity to BZ + SAHA-induced cell death. Accordingly, Myc knockdown markedly reduced the sensitivity of MM cells to BZ + SAHA-mediated apoptosis. Furthermore, activation of Myc was sufficient to...
Source: Cancer Weekly (2008-11-11)
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