Cancer Weekly
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Cancer Vaccines
Data on cancer vaccines reported by C.C. Wang and co-researchers
November 11th, 2008
"Cancer-associated carbohydrate antigens are often found on the surface of cancer cells. Understanding their roles in cancer progression will lead to the development of new therapeutics and high-sensitivity diagnostics for cancers," researchers in Taipei, Taiwan report. "Globo H is a member of this family, which is highly expressed on breast cancer cells. Here, we report the development of a glycan microarray of Globo H and its analogs for measurement of the dissociation constants on surface (K-D,K-surf) with three different monoclonal antibodies (VK-9, Mbr1, and anti-SSEA-3), to deduce their binding specificity. The glycan microarray was also used to detect the amount...
Source: Cancer Weekly (2008-11-11)
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