Cancer Weekly
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Apoptosis
New apoptosis research has been reported by scientists at Dalhousie University
November 11th, 2008
According to recent research from Halifax, Canada, "p53 is a tumor suppressor that integrates signals from different stress induced signalling pathways, regulates cell cycle arrest, senescence, apoptosis and DNA repair. How p53 dictates cell fate is unclear." "As a major transcriptional target of p53 in response to cellular stress, p21 is a key component in cell cycle control and apoptosis, directing an anti-apoptotic response following DNA damage. It is therefore likely that p53-dependent regulation of p21 contributes, at least in part, how p53 influences cellular outcome upon DNA damage. Here we compare the p53-dependent transcriptional regulation of p21 in response...
Source: Cancer Weekly (2008-11-11)
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