Cancer Weekly
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Cancer Gene Therapy
Reports summarize cancer gene therapy research from University of Hong Kong
November 18th, 2008
According to recent research published in the journal Cancer Gene Therapy, "The low in vivo transduction efficiency of recombinant adeno-associated virus (rAAV) and the undesirably strong immunogenicity of adenovirus (rAdv) have limited their clinical utilization in cancer gene therapy. We have previously demonstrated that intratumoral injection of rAAV expressing a C-terminal polypeptide of human telomerase reverse transcriptase (rAAV-hTERTC27) effectively inhibits the growth of glioblastoma xenografts in nude mice." "To further improve its efficacy, we combined rAAV-hTERTC27 with rAdv and investigated the efficiency of the cocktail vectors in vivo. At a...
Source: Cancer Weekly (2008-11-18)
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