Cancer Weekly
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Cancer Gene Therapy
Research data from L.F. Fan and colleagues update understanding of cancer gene therapy
November 18th, 2008
"Background and aims Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is the main active subunit of HIF-1 that promoted tumor cells survival and critical steps in tumor progression and aggressiveness. The authors aimed to investigate the role of HIF-1 alpha and Survivin in colorectal cancer (CRC) progression," researchers in Wuhan, People's Republic of China report. "Materials and methods Plasmid expressing small interfering RNA (siRNA) against HIF-1 alpha was constructed and transfected into LS174T cells with Lipofectamine. The LS174T cells were incubated for 24 h under hypoxic condition. The inhibitory effects of siRNA on HIF-1 alpha gene was determined by...
Source: Cancer Weekly (2008-11-18)
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