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Cancer Gene Therapy
Study results from Pohang University of Science and Technology broaden understanding of cancer gene therapy
November 18th, 2008
According to recent research published in the journal Cancer Gene Therapy, "Protein transduction domains (PTDs) are small peptides that facilitate the transduction of large molecules such as polyproteins, DNA and viruses into a eukaryotic cell. Here, we demonstrated that a novel PTD (HP4) derived from herring protamine appeared to enter C6Bu1 rat glioma cell lines more rapidly than other known PTDs such as Tat, Antp and Hph-1." "Moreover, HP4 significantly enhanced in vitro transduction of recombinant adenoviruses (rAds) into various cancer cell lines, mesenchymal stem cells (MSCs) and dendritic cells, which are relatively resistant to rAd infection. Enhancement...
Source: Cancer Weekly (2008-11-18)
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