Cancer Weekly
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Gene Therapy
Data from G. Jeudy et al provide new insights into gene therapy
November 18th, 2008
According to recent research published in the journal Cancer Gene Therapy, "Immunotherapy has been proposed as a therapeutic strategy in advanced-stage melanomas in which other therapeutic options have little effect. The Staphylococcus enterotoxin A (SEA) has been used to stimulate an antitumoral immune response but its use is hampered by severe systemic side effects." "Here, we show that SEA can be targeted to melanoma cells to limit these side effects. More specifically, we used a nonviral vector, the cationic polymer, polyethylenimine (PEI), to express a transmembrane SEA fusion construct (pSEA-TM) in B16F10-induced subcutaneous melanoma in mice. The efficacy...
Source: Cancer Weekly (2008-11-18)
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