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Cancer Gene Therapy
Ludwig-Maximilians University, Department of Internal Medicine II describes research in cancer gene therapy
November 18th, 2008
Fresh data on cancer gene therapy are presented in the report 'The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer.' According to recent research from Munich, Germany, "We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I. In the current study, we studied the potential of the high-energy alpha-emitter (211)At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of (131)I due to rapid iodide...
Source: Cancer Weekly (2008-11-18)
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