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Cancer Vaccines
Research on cancer vaccines described by scientists at City of Hope Cancer Center
November 18th, 2008
New research, 'A novel approach to evaluate the immunogenicity of viral antigens of clinical importance in HLA transgenic murine models,' is the subject of a report. "Transgenic (Tg) mice expressing HLA class I alleles and lacking murine MHC class I represent a useful model for the pre-clinical evaluation of human vaccines, which focus on induction of CD8(+) T-cell responses. We have developed a platform to be used in Tg mice for exploring the immunogenicity of T-cell targets, whose immunologic epitopes have yet to be defined," researchers in the United States report. "To test the attributes of the evaluation system in the context of an important human pathogen, we have...
Source: Cancer Weekly (2008-11-18)
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