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DNA Research
Research from Eberhard-Karls University, Department of Radiation Oncology has provided new data on DNA research
November 18th, 2008
New research, 'PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro,' is the subject of a report. According to a study from Germany, "As demonstrated recently, ionizing radiation (IR) can mediate phosphorylation of DNA-PKcs in human tumor cells through stimulation of the PI3K/Akt pathway. It is also known that DNA-PKcs directly interacts the X-ray repair cross-complementing group 1 protein (XRCC1) involved in base excision repair (BER)." "Therefore, in the present study we investigated the role of PI3K/Akt activity and DNA-PKcs on XRCC1 expression/stabilization. In contrast to the...
Source: Cancer Weekly (2008-11-18)
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