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Acute Myeloid Leukemia
Scientists at Ohio State University publish new data on acute myeloid leukemia
November 18th, 2008
" RAS mutations occur in 12% to 27% of patients with acute myeloid leukemia (AML) and enhance sensitivity to cytarabine in vitro. We examined whether RAS mutations impact response to cytarabine in vivo," investigators in the United States report. "Patients and Methods One hundred eighty-five patients with AML achieving complete remission on Cancer and Leukemia Group B study 8525 and randomly assigned to one of three doses of cytarabine postremission were screened for RAS mutations. We assessed the impact of cytarabine dose on cumulative incidence of relapse (CIR) of patients with (mutRAS) and without (wild-type; wtRAS) RAS mutations. Thirty-four patients (18%) had RAS...
Source: Cancer Weekly (2008-11-18)
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