Cancer Weekly
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Cancer Gene Therapy
New data from Y.Y. Mahller et al illuminate research in cancer gene therapy
November 18th, 2008
According to recent research from the United States, "Oncolytic herpes simplex viruses (oHSVs) are promising anticancer therapeutics. We sought to characterize the functional genomic response of human cancer cells to oHSV infection using G207, an oHSV previously evaluated in a phase I trial." "Five human malignant peripheral nerve sheath tumor cell lines, with differing sensitivity to oHSV, were infected with G207 for 6 h. Functional genomic analysis of virus-infected cells demonstrated large clusters of downregulated cellular mRNAs and smaller clusters of those upregulated, including 21 genes commonly upregulated in all five lines. Of these, 7 are known to be HSV-1...
Source: Cancer Weekly (2008-11-18)
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