Cancer Weekly
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Gene Therapy
New findings from Nanjing Medical University in the area of gene therapy described
November 25th, 2008
"P-Glycoprotein-mediated multidrug resistance (MDR) is a major hurdle in cancer therapy. P-Glycoprotein is a 170 KD protein encoded by the MDR1 gene," researchers in Nanjing, People's Republic of China report. "Over-expression of P-glycoprotein is considered one of the characteristics of the MDR phenotype, thus down-regulation of the MDR1 gene expression will circumvent MDR partly. RNA interference (RNAi) is a process that can result in sequence-specific gene silencing by cleavage target mRNA. Electroporation has been demonstrated to be a promising and efficient method for gene delivery and has been successfully applied in gene therapy. In our study, by using electric...
Source: Cancer Weekly (2008-11-25)
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