Cancer Weekly
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Apoptosis
Research results from C.M. Connell and co-authors update knowledge of apoptosis
November 25th, 2008
"Survivin (BIRC5) promotes cell division and survival with roles as chromosomal passenger protein and inhibitor of apoptosis protein (LAP). It is overexpressed in many cancers and is associated with resistance to chemotherapy and radiation," scientists in London, the United Kingdom report. "Previously, we showed that expression of survivin within the nucleus of HeLa cells accelerates its degradation and blocks apoptosis inhibition without affecting localization during mitosis. Here, we have investigated the effects of survivin on cell cycle control and potential therapeutic consequences using HeLa and IGROV1 cells expressing wildtype and nuclear-targeted survivin. We...
Source: Cancer Weekly (2008-11-25)
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