Cancer Weekly
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Apoptosis
Studies conducted at INSERM on apoptosis recently published
November 25th, 2008
According to recent research from Marseille, France, "Among the new microtubule-targeted agents, the epothilone family of molecules has shown promising anticancer potential, and clinical trials are currently underway for patupilone (epothilone B) in various cancer indications. In this study, we characterized novel aspects of patupilone's cellular action that may underlie its potent cytotoxicity in human neuroblastoma cells." "Patupilone induced mitochondrial membrane potential collapse, mitochondrial morphological changes, and cytochrome c release, leading to apoptosis. Within the first 2 h, patupilone increased the generation of reactive oxygen species (ROS; i.e.,...
Source: Cancer Weekly (2008-11-25)
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