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B-Cell Lymphoma
Data on B-cell lymphoma described by researchers at Chonbuk National University
November 25th, 2008
"Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma," researchers in South Korea report. "Therefore, we investigated the prevalence and the prognostic impact of SIRTI expression in diffuse large B-cell lymphoma (DLBCL). Immunohistochemical expression of SIRT1, p53, bcl2, CD10, bcl6, and multiple myeloma-1 (MUM1) were evaluated by using a 2mm core from 104 DLBCL patients for tissue microarray. Positive expression of SIRTI was seen in 74% (77/104) of patients. In total DLBCL patients, SIRTI and p53 expression were significantly...
Source: Cancer Weekly (2008-11-25)
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