Cancer Weekly
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B-Cell Lymphoma
Studies from National Cancer Institute update current data on B-cell lymphoma
November 25th, 2008
"Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To investigate whether these DLBCL subtypes arise by distinct pathogenetic mechanisms, we analyzed 203 DLBCL biopsy samples by high-resolution, genome-wide copy number analysis coupled with gene-expression profiling," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "Of 272 recurrent chromosomal aberrations that were associated with gene-expression...
Source: Cancer Weekly (2008-11-25)
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