Cancer Weekly
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Basal Cell Cancer
Reports from C.A. Harwood et al highlight recent research in basal cell cancer
November 25th, 2008
According to recent research from London, the United Kingdom, "The immunosuppressant azathioprine is used to prevent graft rejection after organ transplantation. To investigate whether azathioprine-associated mutagenesis contributes to the high incidence of skin tumours in organ transplant recipients (OTRs), we analysed PTCH gene mutations in 60 basal cell carcinomas (BCC); 39 from OTRs receiving azathioprine and 21 from individuals never exposed to azathioprine." "PTCH was mutated in 55% of all tumours, independent of azathioprine treatment. In both the azathioprine and non-azathioprine groups, transitions at dipyrimidine sequences, considered to indicate mutation by...
Source: Cancer Weekly (2008-11-25)
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