Cancer Weekly
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Fusion Proteins
Studies from H.S.R. Kotturi et al add new findings in the area of fusion proteins
November 25th, 2008
"Tumor cells evade immunosurveillance by elements of the innate immune system, such as natural killer (NK) cells, by downregulating or 'shedding' certain cell-surface molecules like mouse UL16-binding protein-like transcript 1 (MULT1) that can activate NK cells through NK cell receptors such as NKG2D; they also avoid Fas-mediated apoptosis by downregulating its expression. In the present study we report the design and evaluation of the antitumor activity of a novel fusion protein, MULT1E/FasTI, consisting of the extracellular domain of MULT1 and the transmembrane and intracellular domains of Fas," scientists writing in the journal Gene Therapy report. "The fusion...
Source: Cancer Weekly (2008-11-25)
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