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Leukemia Gene Therapy
Investigators at Martin-Luther University target leukemia gene therapy
December 2nd, 2008
Scientists discuss in 'AML1/ETO-induced survivin expression inhibits transcriptional regulation of myeloid differentiation' new findings in leukemia. "The (8;21)(q22;q22) chromosomal translocation, which involves AML1 gene on chromosome 21 and the ETO gene on chromosome 8, generates an AML1/ETO fusion. AML1/ETO is associated with 15% of acute myeloid leukemia (AML) cases," researchers in Halle, Germany report. "The fusion gene is a dominant inhibitor of myeloid-specific genes, notably AML1, CCAAT/enhancer-binding protein-alpha (C/EBPalpha), and myeloperoxidase (MPO). In this study, we investigated the role of antiapoptosis gene survivin as a target of AML1/ETO-related...
Source: Cancer Weekly (2008-12-02)
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