Cancer Weekly
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Apoptosis
New apoptosis findings from Celgene Corporation published
December 2nd, 2008
"Revlimid (R) (Lenalidomide, CC-5013) and CC-4047 are IMiDs (R) immunomodulatory drugs that have been described as having immunomodulatory properties and anti-tumor activity. Here we report proapoptotic effects of CC-5013 and CC-4047 on tumor cells in a co-culture model of PBMC and tumor cells," investigators in the United States report. "CC-5013 and CC-4047 enhanced PBMC activity leading to tumor cell apoptosis in K562/PBMC co-culture model. We also demonstrate that the natural killer (NK) cell population of PBMC was essential in inducing K562 apoptosis. Increases of NK and natural killer T (NKT) cell populations by CC-5013 and CC-4047 was observed along with...
Source: Cancer Weekly (2008-12-02)
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