Cancer Weekly
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Apoptosis
Research on apoptosis reported by D.M. Kuang et al
December 2nd, 2008
According to recent research from Guangzhou, People's Republic of China, "Defects in the CD3/TCR complex and impairment of T cell function are necessary for tumor evasion, but the underlying mechanisms are incompletely understood. We found that culture supernatants from several types of solid tumor cell lines drove human monocytes to become tolerogenic semimature dendritic cells (TDCs)." "Upon encountering T cells, the TDCs triggered rapid down-regulation of CD3 epsilon and TCR-alpha/beta and subsequent apoptosis in autologous T cells. Consistent with these results, accumulation of immunosuppressive DCs coincided with CD3 epsilon down-regulation and T cell deletion in...
Source: Cancer Weekly (2008-12-02)
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