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Cancer Gene Therapy
North Dakota State University, Department of Pharmaceutical Sciences publishes research in cancer gene therapy
December 9th, 2008
A new study, 'KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3,' is now available. According to a study from the United States, "KLF6 (Kruppel-like factor 6) is a zinc finger transcription factor and a tumor suppressor that is frequently mutated in prostate cancer. KLF6 suppresses tumor growth and induces apoptosis in cancer cells through mechanisms still not defined." "Here we show that KLF6 induces apoptosis in prostate cancer cells by ATF3 (activating transcription factor 3) expression. KLF6 binds directly to and activates the ATF3 promoter. ATF3 induced apoptosis when ectopically expressed in cells, whereas knockdown of ATF3 by small...
Source: Cancer Weekly (2008-12-09)
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