Cancer Weekly
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Acute Myeloid Leukemia
Studies from University of Pennsylvania further understanding of acute myeloid leukemia
December 9th, 2008
"Differentiation Syndrome, also known as all-trans retinoic acid (ATRA) syndrome, is a well-described clinical phenomenon occurring in patients with the M3 subtype of acute myeloid leukemia receiving ATRA chemotherapy," scientists in the United States report. "Bexarotene is a novel synthetic compound that selectively binds and activates retinoic X receptors, a subclass of retinoid receptors not targeted by ATRA. We report a patient with refractory non-M3 acute promyelocytic leukemia (AML) who developed differentiation syndrome during bexarotene monotherapy," wrote C.D. Dinardo and colleagues, University of Pennsylvania. The researchers concluded:...
Source: Cancer Weekly (2008-12-09)
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