Cancer Weekly
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Cancer Gene Therapy
Reports summarize cancer gene therapy study results from University of Oxford
December 9th, 2008
"Oncolytic viruses are regulated by the tumor phenotype to replicate and lyse cancer cells selectively. To identify optimal strategies for breast cancer we compared five adenoviruses with distinct regulatory mechanisms: Ad-d/922-947 (targets G1-S checkpoint); Ad-Onyx-015 and Ad-Onyx-017 (target p53/mRNA export); Ad-vKH1 (targets Wnt pathway), and AdEHE2F (targets estrogen receptor/G1-S checkpoint/hypoxic signaling)," scientists in Oxford, the United Kingdom report. "The quantity of virus required to kill 50%, of breast cancer cells after 6 days (EC50, plaque-forming units per cell) was measured. The most potent virus was Ad-d/922-947 (EC50, 0.01-5.4 in SkBr3, MDA-231,...
Source: Cancer Weekly (2008-12-09)
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