Cancer Weekly
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Adenomatous Polyposis Coli
Findings from Royal Melbourne Hospital provide new insights into adenomatous polyposis coli
December 9th, 2008
"The adenomatous polyposis coli (APC) tumour suppressor is a multifunctional protein involved in the regulation of Wnt signalling and cytoskeletal dynamics. Little is known about how APC controls these disparate functions," scientists in Parkville, Australia report. "In this study, we have used APC- and axin-fluorescent fusion proteins to examine the interactions between these proteins and show that the functionally distinct populations of APC are also spatially separate. Axin-RFP forms cytoplasmic punctate structures, similar to endogenous axin puncta. Axin-RFP recruits beta-catenin destruction complex proteins, including APC, b-catenin, glycogen synthase kinase-3-beta...
Source: Cancer Weekly (2008-12-09)
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