Non-Small Cell Lung Cancer

Research from University Hospital provide new insights into non-small cell lung cancer

Published in Cancer Weekly, December 9th, 2008

According to recent research from Parma, Italy, "Epidermal growth factor receptor (EGFR) gene intron I contains a polymorphic single sequence dinucleotide repeat (CA), whose length has been found to inversely correlate with transcriptional activity. This study was designed to assess the role of (CA)(n) polymorphism in predicting the outcome of gefitinib treatment in advanced non-small cell lung cancer (NSCLC)."

"Blood and tumor tissue from 58 patients with advanced NSCLC submitted to gefitinib were collected. EGFR intron I gene polymorphism, along with EGFR gene mutation, gene copy number and immunohistochemistry expression were determined. Moreover, a panel of lung...

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Source: Cancer Weekly (2008-12-09)

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