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Cancer Weekly

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Angiogenesis



Studies from T. Sugino et al have provided new data on angiogenesis



December 9th, 2008

"Hepatocellular carcinoma (HCC) has a tendency for intravascular dissemination leading to a poor prognosis. The importance of the sinusoidal structure of the tumor vasculature in HCC has been implicated in the metastasis formation," scientists in Fukushima, Japan report.

"To clarify the role of tumor angiogenesis in HCC metastasis, we morphologically investigated the interaction of HCC cells with blood vessels during the sequential process of metastasis. Autopsy specimens of 80 patients with HCC were examined with immunohistochemistry using a specific antibody against CD31, a marker for endothelial cells. The most frequent sites of metastasis were the liver (82.5%) and...


Source: Cancer Weekly (2008-12-09)

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