Cancer Weekly
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Angiogenesis
Studies in the area of angiogenesis reported from Tohoku University
December 9th, 2008
"Tocotrienol (T3), unsaturated vitamin E, has recently gained considerable attention as a potent antiangiogenic agent minimizing tumor growth, the exact intracellular mechanisms of which remain poorly understood. Because hypoxia-inducible factor-1 alpha: (HIF-1 alpha), its downstream target vascular endothelial growth factor (VEGF), and other angiogenic factors such as interleukin-8 (IL-8) and cyclooxygenase 2 (COX-2) play critical roles in neovascularization, we tested the hypothesis that the inhibitory effect of T3 on tumor argiogenesis is via regulation of these angiogenic factors," investigators in Sendai, Japan report. "We used 2 cancer cell lines, human colorectal...
Source: Cancer Weekly (2008-12-09)
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