Cancer Weekly
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Cancer Gene Therapy
Researchers from National Cancer Institute report on findings in cancer gene therapy
December 9th, 2008
According to recent research from the United States, "Nuclear export of certain HIV-1 mRNAs requires an interaction between the viral Rev protein and the Rev response element (RRE), a structured element located in the Env region of its RNA genome. This interaction is an attractive target for both drug design and gene therapy, exemplified by RevM10, a transdominant negative protein that, when introduced into host cells, disrupts viral mRNA export." "However, two silent G- >A mutations in the RRE (RRE61) confer RevM10 resistance, which prompted us to examine RRE structure using a novel chemical probing strategy. Variations in region III/IV/V of mutant RNAs suggest a...
Source: Cancer Weekly (2008-12-09)
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