Published in Cancer Weekly, December 9th, 2008
"In the present study the p28(GANK) knockdown-Induced apoptosis in HepG2 cells was prevented by caspase-9 inhibitor (Z-LEHD-FMK). During the knockdown of p28(GANK), mitochondrial translocation of Bax, loss of mitochondrial transmembrane potential (Delta psi m) and release of cytochrome c were observed. In this study, the activation of p38 was found to be critical for the p28(GANK) knockdown-induced apoptosis, as suggested by the finding that...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.