Cancer Weekly
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Apoptosis
Research conducted at University of Pittsburgh has updated our knowledge about apoptosis
December 9th, 2008
"p53-upregulated modulator of apoptosis (PUMA) plays an essential role in p53-dependent apoptosis following DNA damage. PUMA also mediates apoptosis independent of p53," researchers in the United States report. "In this study, we investigated the role and mechanism of PUMA induction in response to serum starvation in p53-deficient cancer cells. Following serum starvation, the binding of Sp1 to the PUMA promoter significantly increased, whereas inhibition of Sp1 completely abrogated PUMA induction. p73 was found to be upregulated by serum starvation and mediate PUMA induction through the p53-binding sites in the PUMA promoter. Sp1 and p73 beta appeared to cooperatively...
Source: Cancer Weekly (2008-12-09)
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