Cancer Weekly
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Cancer Gene Therapy
Scientists at Osaka University discuss research in cancer gene therapy
December 9th, 2008
"Metastasis is a key aspect of tumor malignancy, and several malignant tumors show expression of various rnature N-type glycans. In particular, beta 1-6 branching N-acetylglucosamine (GIcNAc) is abundantly expressed as a part of high-mannose glycans in various highly metastatic cancers," scientists in Osaka, Japan report. "Phaseolus vulgaris agglutinin-L-4 isolectin (L-4-PHA), which adheres to,beta 1-6 GlcNAc specifically, has been used for in situ cancer diagnosis. Bionanocapsules (BNCs), hollow particles with a diameter of approximately 80 nm and composed of hepatitis B surface antigen (HBsAg) and a lipid bilayer, have been developed as human liver-specific...
Source: Cancer Weekly (2008-12-09)
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